Due to poor hygiene and malnutrition, childrens in developing countries frequently suffer from various forms of infections which present as fever. Pyrexia can be defined as when an a.m. temperature is >37.2�°C and p.m. temperature is > 37.7�°C. Herbal medicines are often used as remedies in these conditions. Piper attenuatum (B.Ham.) can cure Pyrexia as mentioned in the literature survey in traditional Indian system of medicine and is not proved scientifically so the aim of the present study is to determine the effect of Piper attenuatum (B.Ham.) on Pyrexia. In the study we use different animal models like TAB-Vaccine induced pyrexia in rabbits and boiled milk induced pyrexia in rabbits. Ethanolic extract of seeds part of plant was obtained by Soxhlet extraction. The extract was found to be safe up to 2000 mg/kg b.w. The Ethanolic extract of seeds part of Piper attenuatum (B.Ham.) contains active constituent like Piperine, Piperlonguminine etc. It may be possible that Piperine causes anti-pyretic activity. Piperine inhibits TNF-alpha (an inflammatory mediator). By inhibiting TNF-alpha it reduce total body temperature & this Inhibition is reversible. The Ethanolic extract of Plant showed significant results in all of the anti-pyretic models. A dose of 200 mg/kg & 400 mg/kg was used. Values are expressed as mean �± S.E.M. Paracetamol was used as standard drug (150mg/kg). The total time period of the study was 6 hr.
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